The current Ofloxacin therapy is associated with high incidence of side effects seen in about 30% of patients. Ofloxacin is incompletely absorbed from GIT, it has absorption window confined to upper GIT. Its bioavailability was reported about 45%-50%, hence it was considered suitable candidate for formulation as gastro-retentive floating drug delivery system. Therefore Ofloxacin gastro retentive Floating tablets were prepared by wet granulation technique using semi-synthetic polymers like HPMC K4M and HPMC K100M for their gel-forming properties and also with natural polymer like pectin. The compressed Ofloxacin floating tablets were evaluated for physical parameters like Hardness, % Friability, weight variation and content uniformity. The formulation F4 was only formulation which was lies in between Pharmacopeial limits. All formulation is also evaluated for floating lag time and total floating time. Formulations containing HPMC K100M has least floating lag time and remained floated for more than 12 hrs. The HPMC alone polymer or low viscosity grade HPMC along with pectin unable to controlled on release rate it release drug >90% in 8 hrs. while in combination of HPMC K100M with pectin it release less than 55% in 8 hrs. The optimized formulation F4 was selected for in-vivo buoyancy test which carried out on Rabbit by using Barium sulphate as a radio opaque agent instead of active medicament. The results indicate that gas powered gastro-retentive floating Tablets of Ofloxacin containing HPMCK100M and pectin provides a better option for controlled release action, improved bioavailability and remained more than 6 hrs. in upper GI tract.
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